Cancer Reversal Program

Metabolic Rebalancing Therapy

Mitochondrial Rejuvenation Therapy

“MRT”

Unless one understands the nature of “cancer” at its most fundamental level (biology and biochemistry), then any attempt to “treat it” or eradicate it is destined to failure. Unfortunately, the fundamental concepts regarding cancer held by convention that form the “scaffolding “of the paradigm in which cancer is viewed and treated are archaic, false and fail to be corroborated by scientific investigation.

The prevailing dogma regarding the nature of cancer, which is taught in medical schools, residencies and fellowship programs that produce our oncologists is called the “somatic mutation origin of cancer”. 
Sadly, and astonishingly, in spite of the fact that this theory is not supported by the very science that the conventional world holds in the highest esteem, it remains the central tenet in oncology.

Israel, and Schaeffer amongst many other researchers around the world have repeatedly demonstrated that malignancy can be reversed close to 100% of the time in “cybrid”s containing “cancer genes” and normal cytoplasm (Israel and Schaeffer, 1987).

A “cybrid” experiment is simply when the DNA of a cancer cell and a healthy cell are interchanged.  If the mutated genes and oncogenes were the cause of the cell becoming a cancerous cell, then the healthy cell would become cancerous once the “cancer DNA” replaced the “healthy DNA”. And likewise, if the healthy (non-cancerous) DNA were placed into a cancer cell in exchange of the ‘cancerous DNA”, the cell should become healthy (non-cancerous).

That is not what happens….in fact, it is the opposite that occurs. 

Cancerous nuclei with their DNA, when placed into the cytoplasm of a healthy cell actually change their genetic expression to accommodate the metabolic requirements of the healthy cytoplasm and hence, the cell becomes healthy (non-cancerous). And the healthy DNA, when placed into the cytoplasm of a cancerous cell, either die due to their inability to adapt or do, in fact adapt by modifying their genetic expression such as to support the cell’s requirement of persistent fermentation (glycolysis). These newly expressed genes are known as “oncogenes”.

Role of the nucleus and mitochondria in the origin of tumors. Summary of a role of the mitochondria in the origin of tumorigenesis, as we previously described (Seyfried, 2012d; Seyfried et al., 2014). Normal cells are shown in green with nuclear and mitochondrial morphology indicative of normal gene expression and respiration, respectively. Tumor cells are shown in red with abnormal nuclear and mitochondrial morphology indicative of genomic instability and abnormal respiration, respectively. “(1) Normal cells beget normal cells. (2) Tumor cells beget tumor cells. (3) Transfer of a tumor cell nucleus into a normal cytoplasm begets normal cells, despite the presence of the tumor-associated genomic abnormalities. (4) Transfer of a normal cell nucleus into a tumor cell cytoplasm begets dead cells or tumor cells, but not normal cells. The results suggest that nuclear genomic defects alone cannot account for the origin of tumors, and that normal mitochondria can suppress tumorigenesis” (Seyfried, 2012d). Original diagram from Jeffrey Ling and Thomas N. Seyfried, with permission.

Replacing dysfunctional mitochondria with normal -healthy mitochondria, restores normal energy production that is required for the normal, healthy, cellular functioning.

So, not only do nuclear-cytoplasmic transfer experiments (“cybrid” experiments) fail to support the somatic mutation theory but, indeed do support the Warburg theory of cancer.

In these cybrid experiments then, after placing a cancer nucleus (DNA) into a normal, healthy cell with efficient mitochondrial function, enough energy is produced so that the oncogenes whose purpose it was to support glycolysis are no longer necessary

Biology of Cancer

The Warburg effect refers to the fact that even in in the presence of oxygen, cancer cells tend to utilize glycolysis (fermentation) rather than “oxidative phosphorylation”, which is 19-20 times more efficient and is the standard process by which all healthy produce the required energy to function.

Aerobic vs Anaerobic Glycolysis and the Abnormal Pasteur Effect

Aerobic glycolysis is defined as glucose uptake with lactic acid production (in the presence of oxygen), hence aerobic.

Aerobic glycolysis occurs when mitochondria become damaged whereas anaerobic glycolysis is the mechanism by which cells produce energy when there is no oxygen.

The Pasteur Effect refers to the fact that if oxygen is introduced into an anaerobically fermenting cell culture, the fermentation or glycolysis ceases and hence no more lactic acid is produced.

Continued production of lactic acid in the presence of oxygen is what is referred to as an abnormal Pasteur effect and is what defines cancer.

Only the cells in the body that are able to utilize glycolysis during periods of intermittent respiratory damage are capable of survival and go on to become cancer.

Cells that are unable to utilize glycolysis in response to respiratory insults will not have enough energy to survive and will die.

Cancer cells, therefore arise from normal cells through a long process of gradual and irreversible damage to their respiratory capacity.

The Warburg effect is actually the direct homeostatic consequence of mitochondrial dysfunction or, as Warburg called, it, “insufficient respiration “(Burk and Schade, 1956; Kaipparettu et al., 2013; Seyfried et al., 2014).

Aerobic glycolysis (Warburg effect), is a homeostatic compensation for damaged mitochondria not the result of mutated genes.

Genetic Changes = Consequence not the cause

Damage to cellular respiration results in retrograde signaling to the nucleus to compensate and hence DNA expression begins changing.

Once established, the instability of the genome (DNA) contributes to further respiratory impairment, genome mutability, and tumor progression.

This understanding is based on the evidence that the integrity of the DNA (genome) is, like all other cellular functions, dependent upon mitochondrial energy homeostasis and all cells require a constant level of useable energy to maintain viability.

One of the major differences between normal cells and cancer cells is not the amount of energy produced but rather the origin of the energy production. In normal cells, 94% of total cellular energy is produced in mitochondria while the other 6% of energy produced occurs in the cytoplasm from glycolysis.

Approximately -56 kJ/mol (ΔG’ATP) is the amount of energy required for cell survival (all cells). 

It is not necessary to understand the following; it is merely necessary to know that the details of these processes are well known to science and that these concepts are not just theoretical, but rather scientific fact.

The condition of prolonged glycolysis results in an unstable genome and all of the other characteristics of cancer.

When glucose is converted to pyruvate by glycolysis, less than 10% of the energy potentially available from the glucose is released, while In the mitochondria, glucose is metabolized completely so that about 30 molecules of ATP (energy molecules) are produced for each molecule of glucose. This is in stark contrast to the 2 molecules of ATP that are produced for each glucose molecule during glycolysis.

Chronic, dysfunctional or absent mitochondria trigger the retrograde (RTG) response that up-regulates (stimulates) the pathways of glycolysis and glutaminolysis (metabolism of glutamine for energy) in order to maintain the -56 kJ/mol (ΔG’ATP) required for cell viability.

This RTG response activates MYC, Ras, HIF-1α, Akt, and M-Tor etc, which are required to maintain glycolysis as the primary mechanism of energy production. Furthermore, the MYC and Ras stimulate cell proliferation, which includes inactivation of pRB, (dependent on mitochondria) and disruption of the pRB signaling additionally contribute significantly to the biology of cancer cells.

Moreover, the loss of p53 also support shifting metabolism towards glycolysis and away from the mitochondria.

All of the signaling abnormalities and other characteristic of cancer cells such as the unlimited ability to replicate are a result of the requirements for glycolysis and glutaminolysis, which are, in turn a direct consequence of impaired respiration or mitochondrial disfunction.

Six hallmarks of cancer.

  1. self-sufficiency in growth signals
  2. insensitivity to growth inhibitory (antigrowth) signals
  3. evasion of programmed cell death (apoptosis)
  4. limitless replicative potential
  5. sustained vascularity (angiogenesis)
  6. tissue invasion and metastasis

Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70. doi: 10.1016/S0092-8674(00)81683-9

And, although these six hallmarks of cancer are necessary to define and understand cancer, aerobic glycolysis (Warburg effect) is the only fundamental metabolic hallmark of malignancy.

It must be kept in mind that there is no specific genetic mutation that is common to all cancers BUT all cancers, by definition must use aerobic glycolysis, regardless of their tissue or cellular origin, whether it be ovary, breast, pancreas, colon, etc.

Cancer is cancer is cancer is cancer and the only difference between any of them is location.

“Location-Location-Location”

 


 

PET Scans

As a side note, this unique metabolic distinction that defines cancer is so fundamental that it has become the basis for PET scans, a uniformly accepted tool in oncology for the detection, staging and management of cancer.

How do PET scans work?

Fluoro-deoxy-glucose (FDG) is injected into the person’s vein and allowed to be distributed throughout the body for about one hour prior to scanning with a sophisticated computerized machine to permit an evaluation known as Positron Emission Tomography.

As bazaar as it may seem, the same profession, which utilizes this technology that relies on the rate of glucose (sugar) uptake to diagnose, stage and manage cancer not only claims that the consumption of sugar has no relationship to malignancies, but they actually promote sugar consumption to their patients by providing cakes, candies and soda during what they refer to as, “treatment”. 

Differentiation

It is worthy of mention that when embryonic cells are developing to form organs, highly efficient energy production is required for both their origination and their maintenance. This process is known as oxidative phosphorylation and the loss of this ability results in a “fail safe” mode of energy production called, “glycolysis”, which cannot support differentiation.  Hence dedifferentiation (loss of distinction as a specific organ) occurs along with rapid proliferation of this non-specific, dysfunctional tissue resulting in what is known as cancer.

This is why pathologists describe the tissue samples they evaluate from suspected tumors as, well differentiated, moderately differentiated or poorly differentiated. When tissues are said to be poorly differentiated, it means that it is unknown from what tissue or organ the cancer originally developed.

Acidity and Hypoxia

(obvious targets of therapy)

Otto Heinrich Warburg, PhD

It is well known that Dr. Otto Warburg, the director of the Kaiser Wilhelm Institute (now Max Planck Institute) for cell physiology in Berlin, Germany in 1923 discovered the cause of cancer and was later awarded the Nobel Prize in Physiology for this discovery in 1931.

In ‘The Metabolism of Tumors’ Warburg demonstrated that all forms of cancer are characterized by two fundamentals, underlying metabolic conditions called, acidosis (acidic microenvironment around cells) and hypoxia (low oxygen).

He further went on to demonstrate that hypoxia and acidosis are always coexistent, like two sides of a coin. Hence, where there is hypoxia, there is acidosis and vice versa.

“All normal cells have an absolute requirement for oxygen, but cancer cells can live without oxygen – a rule without exception.” –   Dr. Otto Warburg

“Deprive a cell 35% of its oxygen for 48 hours and it may become cancerous.”

-Dr. Otto Warburg.  

Dr. Warburg clearly stated repeatedly that the prime cause of cancer is oxygen deficiency (a direct result of toxemia). Toxemia is the term used in those early days to describe accumulated toxins in the body and was most notably and definitely expressed in the 1923 book by John Tilden, MD entitled, Toxemia Explained.

 

And, as Dr. John Tilden so eloquently wrote in the prologue to the book, Toxemia Explained

“From time immemorial man has looked for a savior; and, when not looking for a savior, he is looking for a cure.

He believes in paternalism.

He is looking to get something for nothing, not knowing that the highest price we ever pay for anything is to have it given to us.

Instead of accepting salvation, it is better to deserve it. 

Instead of buying, begging, or stealing, a cure, it is better to stop building disease.

Disease is of man’s own building, and one worse thing than the stupidity of buying a cure is to remain so ignorant as to believe in cures.

The false theories of salvation and cures have built man into a mental mendicant, when he should be the arbiter of his own salvation, and certainly his own doctor, instead of being a slave to a profession that has neither worked out its own salvation from disease nor discovered a single cure in all the age-long period of man’s existence on earth.”

This and many other articles is essential for cancer to exist, grow and spread (metastasize). Hence, it is clear that if we are to expect any significant decrease and eventual elimination of cancer in the long term, the extracellular microenvironment in which tumors exist must be transformed from acidic to alkaline. If this is not directly addressed, the environment that supports tumors will continue to exist and cancer simply cannot be eliminated.

Our collaborative efforts with oncology physicians and professors in the United States, Europe and Asia have allowed us to discover and utilize specific infusions to specifically target and alkalinize the tumor microenvironment.

The two figures below demonstrate the pH (acid-alkaline) differences between normal and cancer microenvironments.

And the following is one of several papers that show that it is possible to alkalinize the tumor microenvironment with bicarbonate.  The problem has heretofore been ‘how do we directly affect the pH of the tumor microenvironment’ since it is abundantly clear that simply improving the pH of the blood, does not in any significant way affect the tumor or its environment.  What is necessary is not simply the infusion of bicarbonate but rather a method of carrying the bicarbonate to the tumor and then releasing it.

Finally, “mission accomplished”. We now have available a simple, non-toxic method of delivering bicarbonate to and rendering alkaline the tumor microenvironment, hence turning off the metabolic triggers that keep cancer alive and growing.

Since mitochondrial failure or dysfunction is the underlying fundamental and essential element necessary for cancer to develop and progress, any hope of sustained reversal of this process requires mitochondrial function to be restored. Again, through our collaborative efforts with biochemists and clinicians worldwide we have been able to discover and incorporate into our program of cancer reversal some very specific tools to accomplish this.

Once mitochondrial proliferation has been stimulated, the necessary raw materials (specific amino acids that feed into the Krebs’s cycle) need to be available to carry out the work of healthy cellular respiration.

Once again, “mission accomplished”.

The tools required to carry out these steps to produce mitochondrial proliferation and then healthy functioning utilize both therapeutic heat and various non-toxic, nutritive infusions.